RT杂志文章SR电子T1 VEGF多态性与儿童哮喘、肺功能和气道反应性的关联JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 1287 OP 1294 DO 10.1183/09031936.00113008 VO 33 IS 6 A1 Sharma, S. A1 Murphy, A. J. A1 Soto-Quiros, M. E. A1 Av188bet官网地址ila, L. A1 Klanderman, B. J. A1 Sylvia, J. S. A1 Celedón, J. C. A1 Raby, B. A. A1 Weiss，S. T. YR 2009 UL //www.qdcxjkg.com/content/33/6/1287.abstract AB血管内皮生长因子(VEGF)是一种与哮喘严重程度有关的血管生成因子。本研究的目的是确定VEGF单核苷酸多态性(SNPs)是否与哮喘、肺功能和气道反应性相关。目前的作者分析了儿童哮喘管理计划(CAMP)中458个白人家庭的10个snp。使用PBAT软件(Golden Helix, Inc.)进行与哮喘、肺功能和气道反应性相关的测试。Bozeman, MT，美国;网址:www.goldenhelix.com)。以家庭和人群为基础，进行气流阻塞的重复措施分析。在哥斯达黎加的412名哮喘儿童及其父母中进行了重复研究。在两个队列中均观察到与哮喘、肺功能和气道反应性的相关性。 SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV1/FVC decline over ∼4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.