@article {sharma1287，作者= {Sharma，S。和Murphy，A。J.和Soto-Quiros，M。E.和Avila，L。和Klanderman，B。J.和Sylvia，J。S.，J。S.和Celed {\'o} n，J。C.Weiss，S。T.}，title = {VEGF多态性与儿童哮喘，肺功能和气道响应率}，音量= {33}，number = {6}，页面= {1287--1294}，年doi = {10.1183/09031936.00113008}，Publisher = {欧188bet官网地址洲呼吸社会}，摘要= {血管内皮生长因子（VEGF）是哮喘严重程度的血管生成因子。本研究的目的是确定VEGF单核苷酸多态性（SNP）是否与哮喘，肺功能和气道反应性有关。目前的作者分析了童年哮喘管理计划（CAMP）中458个白人家庭中的10个SNP。使用PBAT软件（Golden Helix，Inc。Bozeman，MT，美国MT；可在www.goldenhelix.com上获得），对哮喘，肺功能和气道响应进行了关联测试。进行了基于家庭和人群的Revpepepepected措施分析气流阻塞。在412名哮喘儿童及其来自哥斯达黎加的父母中进行了复制研究。在两个队列中都观察到与哮喘，肺功能和气道反应性的关联。SNP RS833058在两个队列中都与哮喘有关。 This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV1/FVC decline over \~{}4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/33/6/1287}, eprint = {//www.qdcxjkg.com/content/33/6/1287.full.pdf}, journal = {European Respiratory Journal} }