TY - JOUR T1 -特发性肺纤维化左室舒张功能障碍:组织多普勒超声心动图研究摩根富林明-欧洲呼吸杂志》乔和J SP - 701 LP - 706欧元——六世10.1183/09031936.00102107 - 31 - 4盟-帕帕多普洛斯,c, e . AU - Pitsiou g . AU - Karamitsos t . d . AU - Karvounis h . i . AU - Kontakiotis t . AU - Giannakoulas g . AU - Efthimiadis g·k . AU - Argyropoulou, p . AU - Parharidis g . e . AU - Bouros d Y1 - 2008/04/01 UR - //www.qdcxjkg.com/content/31/4/701.abstract N2 -这是假定的,特发性肺纤维化(IPF)患者除了右心室(RV)功能障碍外,还表现为左心室(LV)功能损害,这可能会影响疾病的进展和预后。本研究的目的是利用常规和组织多普勒超声心动图评估一组IPF患者的左室功能。表现为轻中度肺动脉高压的IPF患者(平均年龄65±9岁;N = 22)和健康个体(平均年龄61±6岁;N = 22)。常规和组织多普勒超声心动图评价左室和左室收缩和舒张功能。除了预期的右心室功能损害外,与对照组相比,所有患者都表现出左室舒张期充盈到舒张晚期的特征性逆转(舒张早期峰值充盈速度(E)/舒张晚期峰值充盈速度(0.7±0.2 vs 1.5±0.1)。IPF患者在舒张期早期也表现出较低的峰值心肌速度(Em; 5.7±1.1 versus 10.3±1.6 cm·s−1, respectively), higher in late diastole (Am; 8.9±1.3 versus 5.5±0.8 cm·s−1, respectively), lower Em/Am ratio (0.6±0.1 versus 1.9±0.5, respectively) and higher E/Em ratio (10.8±3 versus 6±0.6, respectively), all indicative of LV diastolic dysfunction. Moreover, LV propagation velocity was significantly lower in IPF patients (46±13 versus 83±21 cm·s−1, respectively). Physicians should be aware that patients with idiopathic pulmonary fibrosis exhibit early impairment of left ventricular diastolic function. ER -