作者@article {Brauer879 ={布劳尔,m和隐谷, G. and Smit, H. A. and de Jongste, J. C. and Gerritsen, J. and Postma, D. S. and Kerkhof, M. and Brunekreef, B.}, title = {Air pollution and development of asthma, allergy and infections in a birth cohort}, volume = {29}, number = {5}, pages = {879--888}, year = {2007}, doi = {10.1183/09031936.00083406}, publisher = {European Respiratory Society}, abstract = {Few studies have addressed associations between traffic-related air pollution and respiratory disease in young children. The present authors assessed the development of asthmatic/allergic symptoms and respiratory infections during the first 4 yrs of life in a birth cohort study (n = \~{}4,000). Outdoor concentrations of traffic-related air pollutants (nitrogen dioxide PM2.5, particles with a 50\% cut-off aerodynamic diameter of 2.5 μm and soot) were assigned to birthplace home addresses with a land-use regression model. They were linked by logistic regression to questionnaire data on doctor-diagnosed asthma, bronchitis, influenza and eczema and to self-reported wheeze, dry night-time cough, ear/nose/throat infections and skin rash. Total and specific immunoglobulin (Ig)E to common allergens were measured in a subgroup (n = 713). Adjusted odds ratios (95\% confidence intervals) per interquartile pollution range were elevated for wheeze (1.2 (1.0{\textendash}1.4) for soot), doctor-diagnosed asthma (1.3 (1.0{\textendash}1.7)), ear/nose/throat infections (1.2 (1.0{\textendash}1.3)) and flu/serious colds (1.2 (1.0{\textendash}1.4)). No consistent associations were observed for other end-points. Positive associations between air pollution and specific sensitisation to common food allergens (1.6 (1.2{\textendash}2.2) for soot), but not total IgE, were found in the subgroup with IgE measurements. Traffic-related pollution was associated with respiratory infections and some measures of asthma and allergy during the first 4 yrs of life.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/29/5/879}, eprint = {//www.qdcxjkg.com/content/29/5/879.full.pdf}, journal = {European Respiratory Journal} }