RT期刊文章SR电子T1速尿对犬气管上皮电位差和粘液的急性低血容量影响JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 805 OP 810 DO 10.1183/09031936.04.10021704 VO 24 IS 5 A1 Nakagawa, N.K. A1 Donato-Júnior, F. A1近藤，C.S. A1 King, M. A1 Auler-Júni188bet官网地址or, J.O.C. A1 Saldiva, P.H.N. A1 Lorenzi-Filho，G. YR 2004 UL //www.qdcxjkg.com/content/24/5/805.abstract AB速尿是一种有效的利尿剂，影响呼吸道上皮的水转移，这与上皮间电位差(PD)密切相关。水是决定粘液运输的关键因素;一个重要的肺防御机制，清除颗粒和微生物从呼吸系统。本研究的目的是探讨速尿和低血容量对气管PD和粘液特性的急性影响。对36只雄性混种犬进行麻醉、机械通气和血流动力学监测。他们被随机分为三组:对照组、速尿(40mg静脉注射)+低血容量组和速尿(40mg静脉注射)+容积置换组。分别于干预后0、1、2 h采集气管PD和粘液样本。用磁性微径计和体外蛙腭黏液纤毛输送特性分析了黏液的性质。与对照组相比，速尿将PD降低到中间值，仅在与低血容量血症相关时显著(分别为- 13±5和- 8±2 mV，时间0和2 h)。 In addition to the direct effect of furosemide, these results indicate that hypovolaemia also affects ion transport in the tracheal membrane. Furosemide and hypovolemia have no acute effects on respiratory mucus properties. This work was supported by the São Paulo State Foundation (FAPESP) and the Medical Investigation Laboratory (LIM 5 and LIM 8) of the School of Medicine of São Paulo University.