TY - JOUR T1 - 夸张的支气管收缩，由于与职业剂JF吸入挑战 - 欧洲呼吸杂志JO - EUR呼吸杂志SP - 300 LP - 303 DO - 10.1183 / 09031936.03.00055003 VL - 23 - 2 AU - 马洛，J-L。AU - 卡地，A. AU - Lemière，C. AU - 德贾斯丁，A. AU - 拉布雷克，M. AU - L'Archevêque，J. AU - 佩罗，G. AU - Lesage的，J. AU - Cloutier联系，Y.Y1 - 2004年2月1日UR - //www.qdcxjkg.com/content/23/2/300.abstract N2 - 吸入挑战与职业代理用来确认职业性哮喘的病因。有人建议，使用闭路设备，而不是现实的挑战的方法将提高这些测试的方法。Changes in forced expiratory volume in one second (FEV1) were examined in 496 subjects with “positive specific inhalation challenges”, i.e. changes in FEV1 of ≥20% after exposure to an occupational agent, including 357 subjects exposed by the realistic method, 108 using the closed-circuit method and 31 by both methods. For immediate reactions, 18 of 95 (19%) showed changes in FEV1 of ≥30% with the closed-circuit method, whereas a significantly larger proportion, i.e. 77 of 200 (38.5%), showed such changes using the realistic method. As regards nonimmediate reactions, changes in FEV1 of ≥30% occurred in 16 of 43 (37%) cases with the closed-circuit method as compared to a larger proportion, i.e. 87 of 180 (48%) cases, using the realistic method. This favourable effect was significantly more pronounced in workers with higher levels of bronchial hyperresponsiveness to methacholine. It is concluded that, for agents that can be generated using the closed-circuit method, use of such apparatus results in a smaller proportion of exaggerated bronchoconstriction than does the realistic method, this being particularly true for low-molecular weight agents. ER -