RT期刊文章SR电子T1的影响新生儿筛查和集中治疗长期临床结果和生存的CF患者摩根富林明欧洲呼吸杂志乔和J FD欧洲呼吸学会SP 306欧元OP 315签证官是2 A1 Merelle,主机A1思,摩根大通(J.P. A1 Gerritsen, J . A1 Dankert-Roelse J.E.年2001 UL //www.qdcxjkg.com/content/18/2/306.a188bet官网地址bstract AB实验新生儿筛查程序后囊性纤维化(CF)从1973年到1979年,从1980 - 1997年发生了后续研究。患者治疗专业中心(C)或在当地医院(非)。这项研究的目的是:1)确定之前报道受益于筛选坚持时间和调整后混杂变量;和2)调查中心治疗是否与改进的CF患者的预后有关。被筛选后的患者预后(年代;n = 24)与病人临床发现,出生在(non-S;n = 29)后,检查计划(post-S;n = 39)。此外,预后比较45度至47非患者。多元回归分析用于比较生存和mixed-effects模型回归分析用于比较患者之间的临床结果。 The analyses included the variables screening, centre treatment, sex, meconium ileus and genotype. S patients had a significantly smaller decline in forced expiratory volume in one second (FEV1) (difference +2.74% predicted) and significantly lower immunoglobulin-G (IgG) levels (difference −473.69 mg·dL−1) than non-S patients until 12 yrs of age. At 12 yrs of age, vital capacity was significantly higher in S patients than in non-S patients (difference +362.79 mL). Survival seemed to be best for S patients compared to both non-S and post-S patients. Post-S patients were significantly heavier (difference in sd weight +0.77), had a significantly smaller decline in FEV1 (difference +2.80% pred) and lower IgG levels (difference −453.04 mg·dL−1) than non-S patients until 12 yrs of age. C patients had a significantly improved survival (relative risk (RR) 0.18, 95% confidence interval 0.05–0.57) than non-C patients. Early diagnosis through neonatal screening leads to better preservation of lung function in the long term in cystic fibrosis patients. Management of cystic fibrosis patients in specialized centres improves survival. This study was supported by ZorgOnderzoekNederland (ZON) grants 28.566, 28.566-1 and 28.566-2.