Ty -jour t1-新生儿筛查和集中式治疗对CF患者长期临床结局和生存的影响 - 欧洲呼吸杂志JO -EUR RESSIR J SP -306 LP -306 LP -315 VL -18 IS -2 AU -Mérelle -Mérelle，M.E。Au -Schouten，J.P。Au -Gerritsen，J.Au -Dankert -Roelse，J.E。Y1-2001/08/01 UR -http：//www.qdcxjkg.com/content.com/content/18/2/2/2/2/306.abstract N2-1973年至1979年的囊性纤维化（CF）实验新生儿筛查计划，进行了一项后续研究，于1980 - 1997年进行。患者在专业中心（C）或当地医院（非C）接受治疗。该研究的目的是：1）确定先前报道的筛查收益是否持续到时间和调整后的混杂变量之后；2）研究中心治疗是否与CF患者的预后改善有关。将通过筛查（S; n = 24）检测到的患者的预后与临床检测到的患者（非S; n = 29）和筛查计划后（后S; n = 39）进行了比较。此外，比较了45 C和47例非C患者的预后。多变量回归分析用于比较生存率，并使用混合效应模型回归分析来比较患者之间的临床结果。分析包括变量筛选，中心处理，性别，回肠循环和基因型。 S patients had a significantly smaller decline in forced expiratory volume in one second (FEV1) (difference +2.74% predicted) and significantly lower immunoglobulin-G (IgG) levels (difference −473.69 mg·dL−1) than non-S patients until 12 yrs of age. At 12 yrs of age, vital capacity was significantly higher in S patients than in non-S patients (difference +362.79 mL). Survival seemed to be best for S patients compared to both non-S and post-S patients. Post-S patients were significantly heavier (difference in sd weight +0.77), had a significantly smaller decline in FEV1 (difference +2.80% pred) and lower IgG levels (difference −453.04 mg·dL−1) than non-S patients until 12 yrs of age. C patients had a significantly improved survival (relative risk (RR) 0.18, 95% confidence interval 0.05–0.57) than non-C patients. Early diagnosis through neonatal screening leads to better preservation of lung function in the long term in cystic fibrosis patients. Management of cystic fibrosis patients in specialized centres improves survival. This study was supported by ZorgOnderzoekNederland (ZON) grants 28.566, 28.566-1 and 28.566-2. ER -