RT期刊文章SR电子T1 S和Z Alpha1-抗抗肽等位基因是年轻农民支气管高反应性的危险因素：基因/环境互动的一个例子188bet官网地址A1 Sigsgaard，T A1 BrandSlund，I A1 Omland，O A1 Hjort，C A1 Lund，Ed A1 PedersenAB的几项研究发现，稀有的Pi leacer和哮喘或支气管高反应性（BHR）之间存在关联。这项研究涉及PI-Type对2,308名居住在农村地区的年轻丹麦人中BHR的影响，平均+/- SD年龄为19.7 +/- 2.4岁。进行了访谈，肺功能测试，支气管组胺挑衅和皮肤化测试。确定血清α1-抗胰蛋白酶水平，并通过等电聚焦进行表型，并将受试者分为四组：1）MM和MX；2）MS;3）MZ;4）稀有，即SZ，SS和ZZ。在农民中，发现对房屋尘螨的敏感性的显着积极趋势，从MM组的12％到稀有Pi-Group的22％。 A positive test for trend was found within the Pi-groups in a one-sided test for doctor-diagnosed asthma with a peak prevalence of 40% for these symptoms among smokers in the rare Pi-group. On multiple logistic regression analysis, an increased odds ratio (OR) for BHR was found among farming school attendants with the rare Pi-alleles. The OR (95% confidence interval) was 1.71 (0.84-3.49) for MS, 1.93 (1.10-3.39) for MZ and 4.34 (1.19-15.8) for the rare Pi-group. Such a relationship was not found among the conscripts. These results show that a gene/environment interaction may exist between the farming occupation and the rare Pi-alleles, leading to a higher proportion of bronchial hyperresponsiveness related to the rare Pi-alleles in farming school attendants, in contrast to what is found among other young people living in rural areas.