T1:囊性纤维化中过敏性支气管肺曲霉病。欧洲流行病学研究。流行病学的囊性纤维化JF -欧洲呼吸杂志》乔和J SP - 464 LP - 471欧元六世- 16 - 3盟Mastella G盟——Rainisio M盟——危害,香港非盟-霍德森,我非盟-科赫,C AU -纳瓦罗,J盟——Strandvik B非盟-麦肯齐,SG Y1 - 2000/09/01 UR - //www.qdcxjkg.com/content/16/3/464.abstract N2 -过敏性支气管肺的曲霉病(ABPA)是一个来自烟曲霉属真菌疾病造成过敏反应,尽管该病的发病机制尚不清楚，其在囊性纤维化(CF)中的流行程度仍不清楚。对来自9个欧洲国家224个CF中心的12447名CF患者的囊性纤维化流行病学登记处(ERCF)的数据进行了分析。ABPA诊断的ERCF定义是:a . fumigatus的皮肤试验和血清沉淀素阳性，以及血清免疫球蛋白(Ig)E水平>1,000 U x mL(-1)和其他临床或实验室参数。ERCF人群中总ABPA患病率为7.8%(范围:瑞典为2.1%，比利时为13.6%)。6岁时患病率较低，但此后几乎保持稳定，约为10%。没有观察到性别差异。ABPA对deltaF508/deltaF508基因型患者的影响为8.0%，对deltaF508/G551D、deltaF508/G542X和deltaF508/N1303K基因型患者的影响为5-6%。 ABPA patients presented a lower forced expiratory volume in one second (FEV1) than those without ABPA at any age and the prevalence ranged from 6.6% in patients with FEV1 > or =20-12.9% in those with FEV1 <40%. ABPA was associated with higher rates of microbial colonization, pneumothorax and massive haemoptysis, and with higher IgG serum levels and poorer nutritional status. A mixed model regression analysis of lung function showed that FEVI decline during the follow-up period was not substantially different in ABPA patients compared with non-ABPA patients for any subgroups based on age or disease severity at enrollment. To conclude, allergic bronchopulmonary aspergillosis is a frequent complication in cystic fibrosis patients, particularly after the age of 6 yrs, and it is generally associated with a poorer clinical condition. However, any clear independent influence of allergic bronchopulmonary aspergillosis on the rate of lung function decline in the short term was not shown. ER -