％0期刊论文％A Mastella，G％A Rainisio，M％甲危害，HK％A霍德森，ME％A科赫，C％A纳瓦罗，J％A Strandvik，B％A McKenzie的，SG％T变应性支气管肺曲菌在囊性纤维化。一个欧洲流行病学研究。囊性纤维化％d 2000％Ĵ欧洲呼吸杂志％P 464-471％V 16％N 3％X变应性支气管肺曲霉病的流行病学注册表（ABPA）是从超敏反应响应于烟曲霉引起的疾病，尽管疾病的发病机理是未知的，它的囊性纤维化（CF）患病率仍然定义不清。囊性纤维化对九个欧洲国家从224个CF中心云集12447名CF患者的流行病学登记处（ERCF）数据进行了分析。ABPA诊断ERCF定义是一个正皮肤试验和血清沉淀素到烟曲霉，血清免疫球蛋白（Ig）E水平一起> 1,000ûX毫升（-1）和额外的临床或实验室参数。ABPA在ERCF人群总体患病率为7.8％（范围：瑞典2.1％至13.6％，在比利时）。患病率为低<年龄6年，但此后大约10％是几乎恒定。没有观察到性别差异。 ABPA affected 8.0% of patients with a deltaF508/deltaF508 genotype and 5-6% with deltaF508/G551D, deltaF508/G542X and deltaF508/N1303K genotypes. ABPA patients presented a lower forced expiratory volume in one second (FEV1) than those without ABPA at any age and the prevalence ranged from 6.6% in patients with FEV1 > or =20-12.9% in those with FEV1 <40%. ABPA was associated with higher rates of microbial colonization, pneumothorax and massive haemoptysis, and with higher IgG serum levels and poorer nutritional status. A mixed model regression analysis of lung function showed that FEVI decline during the follow-up period was not substantially different in ABPA patients compared with non-ABPA patients for any subgroups based on age or disease severity at enrollment. To conclude, allergic bronchopulmonary aspergillosis is a frequent complication in cystic fibrosis patients, particularly after the age of 6 yrs, and it is generally associated with a poorer clinical condition. However, any clear independent influence of allergic bronchopulmonary aspergillosis on the rate of lung function decline in the short term was not shown. %U //www.qdcxjkg.com/content/erj/16/3/464.full.pdf