% 0期刊文章%一个小山,S %佐藤,E %野村证券(Nomura) H % Kubo说,K %三浦,M %山下式,T % Nagai, S %和泉,T % T各种脂多糖的潜力释放单核细胞趋化现象的活动从肺上皮细胞和成纤维细胞% D J欧洲呼吸杂志1999% % P 545 - 552 X % V 14% N 3%的细胞毒性虽然脂多糖(LPS)来自铜绿假单胞菌,即鲎变形细胞溶解产物活动,不如从强有力的大肠杆菌0127:B8,铜绿假单胞菌诱发突出持续肺部炎症,如囊性纤维化。本研究旨在考察潜在的多个有限合伙人来自大肠杆菌和铜绿假单胞菌释放活动(MCA)从肺细胞单核细胞的趋化作用。有限合伙人不同刺激A549细胞,BEAS-2B细胞和肺成纤维细胞释放MCA(铜绿假单胞菌> E。杆菌0127:从Difco B8 > 055: B5从σ> 026:B6(σ))。大肠杆菌0127:B8(σ)和0111:B4(σ)没有刺激这些细胞。MCA决心通过棋盘分析。分子筛柱色谱法显示四个趋化现象的山峰。MCA的释放是由环己酰亚胺和脂氧合酶抑制剂抑制的。实验阻止抗体表明MCA的大部分是继发于单核细胞化学引诱物蛋白1 (MCP-1)和集落刺激因子(gm - csf)。因此,这些化学引诱物的浓度检测,发现各种lps刺激的效力MCA与他们在释放MCP-1和GM-GSF效力。 Serum augmented the release of MCP-1 and GM-CSF. However, the differences among LPSs from E. coli and P. aeruginosa in stimulating A549 cells were observed. These data suggest that Pseudomonas aeruginosa lipopolysaccharide may stimulate lung cells to release more monocyte chemotactic activity than lipopolysaccharides derived from Escherichia coli, leading to sustained prominent lung inflammation. %U //www.qdcxjkg.com/content/erj/14/3/545.full.pdf