TY - T1的肺泡巨噬细胞的凋亡信号受体表达增加结节病JF -欧洲呼吸杂志》乔和J SP - 1451 LP - 1454欧元六世- 13 - 6盟戴,H AU - Guzman, J盟——Costabel U Y1 - 1999/06/01 UR - //www.qdcxjkg.com/content/13/6/1451.abstract N2 - Fas受体(FasR)和肿瘤坏死因子(TNF)受体55/60 kDa (TNFR1)被认为是细胞凋亡信号受体。我们知道它们所表达的淋巴细胞与免疫调节和免疫紊乱。本研究旨在探讨FasR和TNFR1表达的肺泡巨噬细胞(AM)在结节病。支气管肺泡灌洗(BAL)在12个患者进行积极的结节病和11个对照组。BAL细胞单克隆抗体使用peroxidase-antiperoxidase方法的特征。Both FasR and TNFR1 were expressed on a higher percentage of AM in sarcoidosis with respect to control subjects (mean +/-sem 40.8+/-3.1% versus 14.9+/-1.7%, p<0.001 and 61.9+/-3.3% versus 23.1+/-4.1%, p<0.001, respectively). There was a close relationship between the expression of FasR and TNFR1 on AM (r = 0.86, p<0.001). The percentages of FasR+ AM and TNFR1+ AM were in direct proportion to the percentage of BAL lymphocytes (r = 0.75 and 0.84), the CD4/CD8 ratio (r = 0.78 and 0.78), and the percentage of the CD14+ AM subset (r = 0.77 and 0.87), p<0.001 for all correlations. This study indicates that alveolar macrophages expressing apoptotic receptors are increased in patients with active sarcoidosis. Further studies are required to determine whether these alveolar macrophages from patients with sarcoidosis undergo apoptosis more readily than those from control subjects. ER -