SR Electronic T1 Increased expression of apoptosis signaling receptors by alveolar macrophages in sarcoidosis JF European Respiratory Journal JO Eur Respir J FD European Respiratory188bet官网地址 Society SP 1451 OP 1454 VO 13 IS 6Fas受体(FasR)和肿瘤坏死因子(TNF)受体55/60 kDa (TNFR1)被认为是凋亡信号受体。已知它们通过淋巴细胞表达，与免疫调节和免疫紊乱有关。本研究旨在研究结节病患者肺泡巨噬细胞(AM)中FasR和TNFR1的表达。对12例活动性结节病患者和11例正常人进行支气管肺泡灌洗(BAL)。单克隆抗体采用过氧化物酶-抗过氧化物酶法对BAL细胞进行表征。与对照组相比，FasR和TNFR1在结节病中AM的表达率更高(平均+/-sem 40.8+/-3.1% vs 14.9+/-1.7%， p<0.001; 61.9+/-3.3% vs 23.1+/-4.1%， p<0.001)。AM上FasR和TNFR1的表达密切相关(r = 0.86, p<0.001)。FasR+ AM和TNFR1+ AM的百分比与BAL淋巴细胞百分比(r = 0.75和0.84)、CD4/CD8比值(r = 0.78和0.78)和CD14+ AM亚群百分比(r = 0.77和0.87)成正比，p<0.001。本研究表明，活动性结节病患者肺泡中表达凋亡受体的巨噬细胞增多。 Further studies are required to determine whether these alveolar macrophages from patients with sarcoidosis undergo apoptosis more readily than those from control subjects.