TY - T1的白细胞介素- 10”水平,减少痰在支气管哮喘,慢性阻塞性肺病和吸烟者JF -欧洲呼吸杂志》乔欧元和J SP - 309 LP - 314 - 10.1183 / 09031936.99.14230999六世- 14 - 2非盟Takanashi年代AU -长谷川,Y盟——Kanehira Y盟——山本,K盟——藤本,佐藤晴K AU - K AU -冈,K Y1 - 1999/08/01 UR - //www.qdcxjkg.com/content/14/2/309.abstract N2 -细胞因子白介素(IL) -10是一个强有力的监管,减少炎症反应。这项研究调查了il - 10水平气道是否减少慢性气道炎症与哮喘或慢性阻塞性肺疾病(COPD)。痰是来自12个健康不吸烟,哮喘病人10健康的吸烟者,16和7个COPD患者通过sputum-induction方法。il - 10水平通过酶联免疫吸附试验测定,采用免疫分析。痰的il - 10水平显著低于哮喘和慢性阻塞性肺病患者和健康的吸烟者相比,在健康不抽烟(不抽烟,68.0 + / - -11.3;吸烟者,45.3 + / - -7.8;哮喘、26.7 + / - -4.0;慢性阻塞性肺病,18.0 + / - -2.3 pg x mL (1);p<0.05 for nonsmokers versus the other groups). The percentage of IL-10-positive cells in the sputum was also significantly lower in asthma and COPD and in smokers (nonsmokers, 13.2+/-1.7; smokers, 6.4+/-1.8; asthma, 5.4+/-3.5; COPD, 3.5+/-1.6%; p<0.05 for nonsmokers versus the other groups). The IL-10-positive cell appeared morphologically to be the macrophage. These data suggest that the reduced level of interleukin-10 within the airways plays a role in the pathogenesis of chronic airway inflammation in asthma and chronic obstructive pulmonary disease. ER -