RT期刊文章SR电子T1痰endothelin-1增加在囊性纤维化和慢性阻塞性肺病摩根富林明欧洲呼吸杂志乔和J FD欧洲呼吸学会SP 1288欧元OP 1292签证官13是A1查尔默斯,瓦A1麦克劳德,KJ A1·S A1汤森,LJ A1创造C A1堆栈,黑洞A1汤森,数控年1999 UL //www.qdcxjkg.com/content/188bet官网地址13/6/1288.abstract AB许多囊性纤维化(CF)气流梗阻患者,伴有支气管周围和细支气管周围纤维化。内皮素(ET)-1是一种有效的支气管收缩剂，对气道平滑肌具有有丝分裂活性。痰中ET-1的水平是否支持ET-1在CF气流阻塞时气道重塑中的假定作用?测定了12例未加重期CF患者(自发痰)、17例正常对照组(诱导痰)和9例稳定期慢性阻塞性肺疾病(COPD)患者(7例自发痰)血浆、唾液和痰中ET-1水平。进行总痰细胞计数和差异痰细胞计数。中位(四分位范围)痰ET-1水平在CF组(77.6 (29.0-122.8)pg x mL(-1))高于正常组(6.00 (2.8-14.8)pg x mL(-1))和COPD组(16.4 (6.8-38.2)pg x mL(-1))， COPD组高于正常组。与正常受试者(3.1 (1.7-4.4)pg x mL(-1))和COPD (3.3 (2.7-4.2) pg x mL(-1)相比，CF (5.3 (3.2-6.0) pg x mL(-1))的血浆ET-1水平略有升高。所有组的痰和唾液ET-1水平均显著高于血浆水平，提示其在呼吸道局部产生或释放。痰细胞差异计数显示，与正常受试者相比，CF和COPD患者有明显的嗜中性粒细胞。 Sputum endothelin-1 concentrations are elevated in cystic fibrosis sputum compared to chronic obstructive pulmonary disease, and in cystic fibrosis and chronic obstructive pulmonary disease compared to normal subjects. The role of endothelin-1 in contributing to airflow obstruction through bronchoconstriction and mitogenesis in cystic fibrosis needs now to be explored.