%0杂志文章%A Shivakoti, Rupak纽曼，John W. A Hanna, Luke Elizabeth %A Queiroz, Artur T.L. %A Borkowski, Kamil %A Gupte, Akshay N. %A Paradkar, Mandar %A Satyamurthi, Pattabiraman %A Kulkarni, Vandana %A Selva, Murugesh %A Pradhan, Neeta %A Shivakumar, Shri Vijay Bala Yogendra %A Natarajan, Saravanan %A Karunaianantham, Ramesh %A Gupte, Nikhil %A Thiruvengadam, Kannan %A Fiehn, Oliver %A Bharadwaj, Renu %A Kagal, Anju %A Gaikwad, Sanjay %A Sangle, Shashikala %A Golub，Jonathan E. A Andrade, Bruno B. A Mave, Vidya Gupta, Amita Padmapriyadarsini, Chandrasekaran宿主脂质组与结核病治疗失败J欧洲呼吸杂志宿主脂质在结核病(TB)发病机制中发挥重要作用。结核病治疗开始(基线)时宿主脂质是否会影响随后的治疗结果尚未得到很好的描述。我们使用无偏脂组学研究宿主脂类与结核病治疗失败的前瞻性关联。方法采用一项前瞻性队列研究中嵌套的病例对照研究(n=192)，调查成人肺结核患者基线血脂与结核病治疗失败的关系。病例(n=46)被定义为结核病治疗失败，而对照组(n=146)为没有治疗失败的患者。用液相色谱质谱技术测定复合脂质和炎性脂质介质。采用调整后最小二乘回归评估组间差异。此外，机器学习识别出曲线下面积(AUC)最高的脂类，以分类病例和对照。结果调整错误发现率后，对照组和治疗失败组32种血脂的基线水平存在差异。 Treatment failure was associated with lower baseline levels of cholesteryl esters and oxylipin, and higher baseline levels of ceramides and triglycerides compared to controls. Two cholesteryl ester lipids combined in a unique classifier model provided an AUC of 0.79 (95% CI 0.65–0.93) in the test dataset for prediction of TB treatment failure.Conclusions We identified lipids, some with known roles in TB pathogenesis, associated with TB treatment failure. In addition, a lipid signature with prognostic accuracy for TB treatment failure was identified. These lipids could be potential targets for risk-stratification, adjunct therapy and treatment monitoring.In this study, unbiased lipidomics were used to identify host lipids prospectively associated with TB treatment failure. These lipids, some with known roles in TB pathogenesis, could be potential targets for adjunct therapy and treatment monitoring. https://bit.ly/3vHZ0Ec %U //www.qdcxjkg.com/content/erj/59/1/2004532.full.pdf