TY -的T1 - e的检测和描述xtracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03024-2020 VL - 58 IS - 2 SP - 2003024 AU - Lucchetti, Donatella AU - Santini, Giuseppe AU - Perelli, Luigi AU - Ricciardi-Tenore, Claudio AU - Colella, Filomena AU - Mores, Nadia AU - Macis, Giuseppe AU - Bush, Andrew AU - Sgambato, Alessandro AU - Montuschi, Paolo Y1 - 2021/08/01 UR - //www.qdcxjkg.com/content/58/2/2003024.abstract N2 - Extracellular vesicles, nano-sized (20–1000 nm) membranous structures released from cells, play critical roles in both physiological and pathological processes [1]. Extracellular vesicles can be classified based on their size into small (sEVs; <200 nm, also known as exosomes) and medium (mEVs; >200 nm, also known as microvesicles) [1]. Extracellular vesicles might be a target for personalised medicine, given their content and biological origin [2]. Indeed, extracellular vesicles detected in various biological fluids, including sputum supernatants, mucus, epithelial lining fluid, the pulmonary circulation and bronchoalveolar lavage fluid represent a unique tool for both investigating the pathophysiology of respiratory disease and for biomarker discovery [2, 3].Small and medium extracellular vesicles, identified and characterised in exhaled breath condensate and induced sputum supernatants, might provide pathophysiological insights and novel biomarkers in severe asthma and COPD patients https://bit.ly/3fiTnXY ER -