TY - JOUR T1 -支气管扩张影响测量(BIM)的验证:JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1185 /13993003.03156-2020 VL - 57 IS - 5 SP - 2003156 AU - Crichton, Megan L. AU - Dudgeon, Emily K. AU - Shoemark, Amelia AU - Chalmers，现有的用于支气管扩张试验的生活质量和症状工具要么不是疾病特异性的，要么是复杂的，并不是始终有效的。我们开发了一个简单的患者报告的可视化模拟结果测量，支气管扩张影响测量(BIM)，用于临床研究，包括临床试验。方法在苏格兰东部某三级转诊诊所就诊的支气管扩张患者，在2周和6个月后重复填写BIM问卷和基线时的生活质量支气管扩张问卷。我们通过评估急性加重期间的变化来评估内部一致性、重测信度、建构效度和反应性。结果共纳入173例患者。8个领域(咳嗽、痰、喘、疲劳、活动、一般健康、控制、恶化)表现出良好的内部一致性(Cronbach's α 0.93)。在2周的时间内，类内相关系数显示出良好的可靠性:咳嗽(0.79,95% CI 0.70-0.85)、咳痰(0.86,95% CI 0.80-0.90)、呼吸困难(0.82,95% CI 0.82 - 0.87)、疲倦(0.88,95% CI 0.82 - 0.91)、活动(0.84,95% CI 0.77-0.89)、一般健康(0.81,95% CI 0.74-0.87)、对照(0.83,95% CI 0.80 - 0.88)和恶化(0.71,95% CI 0.60-0.79)。域与支气管扩张的严重程度和加重史密切相关。 Both distribution and patient-based methods estimated the minimal clinically important difference for each domain as 1.5 points on a 10-point scale. Statistically significant changes in all BIM domains were observed during an acute exacerbation.Conclusion The BIM is a simple patient-reported outcome. This study validates the internal consistency, reliability, construct validity and response of the tool at acute exacerbation. Further validation of the tool is now required.This study validates a novel patient-reported outcome for patients with bronchiectasis. The Bronchiectasis Impact Measure (BIM) is repeatable, content valid and responsive to change, and may be a useful outcome measure for testing new therapies. https://bit.ly/3pean44 ER -