Ty -jour t1-基因组全基因组协会研究哮喘病毒的研究，尽管吸入了皮质类固醇JF-欧洲呼吸杂志JO -EUR RESSIR J DO -10.1183/13993003.03388-2020 VL -57 IS -57 IS -5 SP -5 SP -2003388 AU -HERNANDEZ -PACHECOAu -Vijverberg，Susanne J. Au -Herrera -Luis，Esther Au -Li，Jiang Au -Sio，Sio，Yang Yie Au -Granell，Raquel Au -Corrales，Almudena au -Maroteau -Maroteau -Cyrielle，Cyrielle Au -Lethem，Ryan Au -Pererez -Garcia-, Javier AU - Farzan, Niloufar AU - Repnik, Katja AU - Gorenjak, Mario AU - Soares, Patricia AU - Karimi, Leila AU - Schieck, Maximilian AU - Pérez-Méndez, Lina AU - Berce, Vojko AU - Tavendale, Roger AU- Eng，Celeste au -Sardon，Olaia au -Kull，Inger Au -Mukhopadhyay，Somnath au -Pirmohamed，Munir au -Verhamme，Katia M.C.Au -Burchard，Esteban G. Au -Kabesch，Michael Au -Hawcutt，Daniel B. Au -Melén，Erik Au -Potočnik，UrošAu -Chew，Fook Tim Au -Tantisira -Tantisira，Kelan G.，Colin N. au -Flores，Carlos au -Pino -Yanes，Maria au -Maitland -Van der Zee，Anke H. A2-，Y1-2021/05/01 Ur -http：//www.qdcxjkg.com/content.com/content/57/5/2003388.Abstract N2-对用吸入皮质类固醇（IC）（IC）的响应响应哮喘治疗（ICS）的基本原理已在个体和人群中描述，这表明遗传因素的贡献。尽管如此，迄今为止，仅确定了少数基因。我们的目的是确定尽管在欧洲儿童和年轻人中使用了ICS，但仍与哮喘恶化有关，并验证非欧洲人的发现。此外，我们探索了基因企业的富集分析是否可以暗示潜在的新型哮喘疗法。用八项研究从八项研究中接受ICS治疗的2681名欧洲血统儿童中测试了全基因组全基因组关联研究（GWAS）。在538名欧洲哮喘患者中，随访了暗示性关联信号进行复制。 Further evaluation was performed in 1773 non-Europeans. Variants revealed by published GWAS were assessed for replication. Additionally, gene-set enrichment analysis focused on drugs was performed.Results 10 independent variants were associated with asthma exacerbations despite ICS treatment in the discovery phase (p≤5×10−6). Of those, one variant at the CACNA2D3-WNT5A locus was nominally replicated in Europeans (rs67026078; p=0.010), but this was not validated in non-European populations. Five other genes associated with ICS response in previous studies were replicated. Additionally, an enrichment of associations in genes regulated by trichostatin A treatment was found.Conclusions The intergenic region of CACNA2D3 and WNT5A was revealed as a novel locus for asthma exacerbations despite ICS treatment in European populations. Genes associated were related to trichostatin A, suggesting that this drug could regulate the molecular mechanisms involved in treatment response.A genome-wide association study of asthma exacerbations despite inhaled corticosteroid treatment in childhood asthma revealed a novel association at the CACNA2D3-WNT5A locus and suggested trichostatin A as a potential asthma therapy https://bit.ly/3nxWLPD ER -