TY - T1的肺泡的硬化是一个崩溃n ultrastructural finding in a COVID-19 patient JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.04165-2020 VL - 57 IS - 5 SP - 2004165 AU - Ochs, Matthias AU - Timm, Sara AU - Elezkurtaj, Sefer AU - Horst, David AU - Meinhardt, Jenny AU - Heppner, Frank L. AU - Weber-Carstens, Steffen AU - Hocke, Andreas C. AU - Witzenrath, Martin Y1 - 2021/05/01 UR - //www.qdcxjkg.com/content/57/5/2004165.abstract N2 - The delicate alveolar blood–air barrier is a primary target in coronavirus disease 2019 (COVID-19). Its micro-architecture consists of an alveolar epithelium composed of type I and type II cells and covered with surfactant, a thin interstitium and a capillary endothelium. Of particular relevance for the pathogenesis of severe COVID-19 is the infection of type II alveolar epithelial cells [1]. Based on their dual function as producers of surfactant and as precursors for both epithelial cell types, surfactant alterations and aberrant epithelial regeneration can be expected.Electron microscopy reveals collapse induration with alveolar epithelial cell death, basal lamina denudation, collapse and sealing of alveoli in a COVID-19 patient, implicating surfactant dysfunction and alveolar instability in fibrosis initiation https://bit.ly/38yEX2gThe expert technical assistance by Petra Schrade (Core Facility for Electron Microscopy, Charité) is highly acknowledged. ER -