TY - T1的阻塞性系统性红斑狼疮的遗传分析ep apnoea discovers a strong association with cardiometabolic health JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03091-2020 VL - 57 IS - 5 SP - 2003091 AU - Strausz, Satu AU - Ruotsalainen, Sanni AU - Ollila, Hanna M. AU - Karjalainen, Juha AU - Kiiskinen, Tuomo AU - Reeve, Mary AU - Kurki, Mitja AU - Mars, Nina AU - Havulinna, Aki S. AU - Luonsi, Elina AU - Mansour Aly, Dina AU - Ahlqvist, Emma AU - Teder-Laving, Maris AU - Palta, Priit AU - Groop, Leif AU - Mägi, Reedik AU - Mäkitie, Antti AU - Salomaa, Veikko AU - Bachour, Adel AU - Tuomi, Tiinamaija AU - FinnGen AU - Palotie, Aarno AU - Palotie, Tuula AU - Ripatti, Samuli Y1 - 2021/05/01 UR - //www.qdcxjkg.com/content/57/5/2003091.abstract N2 - There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries.We estimated 0.08 (95% CI 0.06–0.11) heritability and identified five loci associated with OSA (p<5.0×10−8): rs4837016 near GAPVD1 (GTPase activating protein and VPS9 domains 1), rs10928560 near CXCR4 (C-X-C motif chemokine receptor type 4), rs185932673 near CAMK1D (calcium/calmodulin-dependent protein kinase ID) and rs9937053 near FTO (fat mass and obesity-associated protein; a variant previously associated with body mass index (BMI)). In a BMI-adjusted analysis, an association was observed for rs10507084 near RMST/NEDD1 (rhabdomyosarcoma 2 associated transcript/NEDD1 γ-tubulin ring complex targeting factor). We found high genetic correlations between OSA and BMI (rg=0.72 (95% CI 0.62–0.83)), and with comorbidities including hypertension, type 2 diabetes, coronary heart disease, stroke, depression, hypothyroidism, asthma and inflammatory rheumatic disease (rg>0.30). The polygenic risk score for BMI showed 1.98-fold increased OSA risk between the highest and the lowest quintile, and Mendelian randomisation supported a causal relationship between BMI and OSA.Our findings support the causal link between obesity and OSA, and the joint genetic basis between OSA and comorbidities.Five OSA-associated loci were found, highlighting the causal link between obesity and OSA, and providing evidence for non-BMI-dependent effects. OSA comorbidities were correlated genetically for OSA, showing these diseases may have a shared genetic basis. https://bit.ly/36Rfq1Y ER -