TY -的T1连接这些点:公司的角色nnexins in the pulmonary vascular response to hypoxia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.04573-2020 VL - 57 IS - 3 SP - 2004573 AU - Witzenrath, Martin AU - Kuebler, Wolfgang M. Y1 - 2021/03/01 UR - //www.qdcxjkg.com/content/57/3/2004573.abstract N2 - We read with great interest the recent manuscript by Bouvard et al. [1], which suggested the gap junctional protein connexin-43 (Cx43) to be a promising target for the treatment of chronic hypoxic pulmonary hypertension (CHPH). Therein, the authors demonstrated increased Cx43 expression in human pulmonary arteries of CHPH patients, while heterozygous Cx43 deficient mice were partially protected from CHPH.Gap junctions, composed of connexins 37, 40 or 43, mediate the pulmonary vascular response to acute and chronic hypoxia as they propagate the hypoxic signal from the site of gas exchange retrogradely to the feeding arteri(ol)es https://bit.ly/3orJKXM ER -