TY - T1的回答:固定呼吸协议multiple-breath-washout testing: truly an option in children? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00189-2021 VL - 57 IS - 3 SP - 2100189 AU - Verbanck, Sylvia AU - Schuermans, Daniel AU - Paiva, Manuel AU - Robinson, Paul D. AU - Vanderhelst, Eef Y1 - 2021/03/01 UR - //www.qdcxjkg.com/content/57/3/2100189.abstract N2 - We agree with the challenges discussed by A-C. Kentgens and co-workers for the adoption of fixed breathing protocols outside the adult range assessed in our study, but we want to clarify that we were not recommending imposing 1 L breathing outside the age range studied [1]. The main intention of our research letter was to illustrate the impact of different breathing protocols on variability of multiple breath washout (MBW) outcomes by choosing a cohort where both protocols were readily feasible. By expressing the tidal volume (VT) dependence that we observed in adults in terms of mL·kg−1, we then aimed to make observations about whether the pronounced variability shown with tidal breathing may affect existing paediatric data. Consistent with a concurrent publication by Handley et al.Adult studies point to two sources of lung clearance index variability that could be explored to improve LCI sensitivity https://bit.ly/36oRJ1I ER -