TY -的T1 -识别基于肺外治疗的哮喘表型特征JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00240 -2020欧元六世- 57 - 1 SP - 2000240 AU - Freitas,帕特里夏·杜阿尔特盟-泽维尔,Rafaella语盟——麦当劳,凡妮莎玛丽AU -吉布森,彼得•杰拉德AU - Cordova-Rivera劳拉盟——Furlanetto库托卡琳娜AU - de Oliveira乔伊斯马拉盟——Carvalho-Pinto Regina玛丽亚盟——Cukier Alberto AU -史堤玛拉斐尔AU -卡瓦略,Celso Ricardo Fernandes Y1 - 201/01/01 UR - //www.qdcxjkg.com/content/57/1/2000240.abstract N2 -哮喘是一种异质性和复杂的疾病，以前没有报道过基于肺外可治疗特征的哮喘表型描述。本研究的目的是根据临床、功能、人体测量学和心理学特征，在中度至重度哮喘患者中识别和特征聚类。这是一项横断面多中心研究，涉及巴西和澳大利亚的研究中心。连续招募患有中度至重度哮喘的参与者(n=296)。评估了体力活动和久坐时间、临床哮喘控制、人体测量数据、肺功能以及心理和健康状况。采用分层聚类分析对参与者进行分类，采用方差分析、Kruskal-Wallis检验和卡方检验对聚类进行比较。多个逻辑和线性回归模型被用来评估变量之间的关联。我们确定了四个聚类:1)进行体力活动的哮喘控制患者;2)不运动且久坐不动的哮喘患者;3)患有不受控制的哮喘和低体力活动的参与者，他们同时肥胖，并有焦虑和/或抑郁症状;4)缺乏运动、久坐不动、肥胖并有焦虑和/或抑郁症状的哮喘患者。久坐时间长、女性性行为和焦虑症状与病情恶化风险增加有关，而更活跃则是住院治疗的保护因素。 Asthma control was associated with sex, the occurrence of exacerbation, physical activity and health status.Physical inactivity, obesity and symptoms of anxiety and/or depression were associated with worse asthma outcomes, and closely and inextricably associated with asthma control. This cluster analysis highlights the importance of assessing extrapulmonary traits to improve personalised management and outcomes for people with moderate and severe asthma.Cluster analysis based on extrapulmonary treatable traits in people with moderate-to-severe asthma indicates that physical inactivity, higher levels of sedentary time, symptoms of anxiety and depression, and obesity are associated with worse outcomes. https://bit.ly/2ATv1Ce ER -