％0期刊文章％freitas，Patricia Duarte％Xavier，RafaellaFrança％A McDonald，Vanessa Marie％A Gibson，Peter Gerard％A Cordova-Rivera，Laura％A Furlanetto，Karina Couto a de Oliveira，Joice Mara％ACarvalho Pinto，Regina Maria％cukier，Alberto％A stelmach，Rafael％A Carvalho，Celso Ricardo Fernandes％T鉴定基于可肺外治疗特质的哮喘表型，可基于可肺外的特质D 2021％D 2021％R 10.1183/13993003.003.003.0033003300240-2020％Juorcor JourneP 2000240％v 57％n 1％X哮喘是一种异质且复杂的疾病，并且先前尚未报道基于肺外可治疗性状的哮喘表型的描述。这项研究的目的是识别和表征基于临床的簇，并表征基于临床的特征中度至重度哮喘的参与者的功能，人类学和心理特征。这是一项横断面的多中心研究，涉及来自巴西和澳大利亚的中心。与中度至重度哮喘的参与者（n = 296）被连续招募。评估了体育活动和久坐时间，临床哮喘控制，人体测量数据，肺功能以及心理和健康状况。参与者通过分层群集分析对参与者进行分类，并使用ANOVA，KRUSKAL – WALLIS和卡方检验进行了比较。进行了多个逻辑和线性回归模型，以评估变量之间的关联。我们确定了四个群集：1）患有受控哮喘的参与者；2）患有不受控制的哮喘的参与者身体不活跃，更久坐；3）患有哮喘和低身体活动的参与者，他们也肥胖，经历了焦虑和/或抑郁症状； and 4) participants with very uncontrolled asthma who were physically inactive, more sedentary, obese and experienced anxiety and/or depression symptoms. Higher levels of sedentary time, female sex and anxiety symptoms were associated with increased odds of exacerbation risk, while being more active showed a protective factor for hospitalisation. Asthma control was associated with sex, the occurrence of exacerbation, physical activity and health status.Physical inactivity, obesity and symptoms of anxiety and/or depression were associated with worse asthma outcomes, and closely and inextricably associated with asthma control. This cluster analysis highlights the importance of assessing extrapulmonary traits to improve personalised management and outcomes for people with moderate and severe asthma.Cluster analysis based on extrapulmonary treatable traits in people with moderate-to-severe asthma indicates that physical inactivity, higher levels of sedentary time, symptoms of anxiety and depression, and obesity are associated with worse outcomes. https://bit.ly/2ATv1Ce %U //www.qdcxjkg.com/content/erj/57/1/2000240.full.pdf