Ty-jour t1 - 慢性阻塞性肺病的运动培训：肌肉o _{2 运输塑性JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.04146-2020 SP - 2004146 Au - Broxterman，RyanM. Au - Wagner，Peter D. Au - Richardson，Russell S. Y1 - 2021/01/01 Ur - //www.qdcxjkg.com/content/early/2021/01/08/13993003.04146-2020.AbstractN2 - 慢性阻塞性肺病（COPD）的患者骨骼肌中的对流O2运输和弥漫性运输，骨骼肌患者显着降低。然而，尚不清楚这些峰值肌肉O2摄取的决定因素（v̇mo2peak）如何响应COPD患者的运动培训。因此，本研究的目的是评估骨骼肌O2转运决定簇的骨骼肌O2转运决定簇的可塑性，在患者中，在8例严重COPD的8例患者中测量了单腿膝关节伸展运动训练的8周（强制呼气量在1 s（FEV1）±SEM = 0.9±0.1L）和8个健康，匹配的控制中。股动脉和静脉血液样品和热渗透评估的腿血流量用于确定最大运动的肌肉O2运输和利用率预先训练，两种COPD中的v 1mo2peak（从271±29〜342〜291±29〜342）±35毫升·min-1）和对照（通过418±37至553±41毫升·min-1），恢复v̇mo2peak，仅达到训练预训练v̇mo2peak的~80％。COPD中的肌肉扩散O2转运同样增加（从6.6±0.9至9.1±0.9 mL·mmHG-1）和对照（从10.4±0.7至14.1±0.8ml·min·mmhg·mmhg-1），患者达到预训练控制值的约90％。相比之下，肌肉对流O2转运仅在对照中显着增加（从688±57至865±69毫升·min-1），将COPD的患者（438±45与491±51毫升·min-1相比）在训练前控制价值的~70％。当COPD中的肌肉扩散O2运输很大程度上通过运动训练来恢复，V̇mo2peak在肌肉对流O2运输中的有限可塑性受到限制。最近在欧洲呼吸期刊上被接受了公布的特性。。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Broxterman reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Wagner reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Richardson reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;. ER -}