TY - JOUR T1 -运动训练治疗慢性阻塞性肺病:肌O₂ Transport可塑性JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.04146-2020 SP - 2004146Russell S. Y1 - 2011/01/01 UR - //www.qdcxjkg.com/content/early/2021/01/08/13993003.04146-2020.abstract N2 -在慢性阻塞性肺疾病(COPD)患者中，骨骼肌的对流O2输送和骨骼肌内的弥漫性O2输送均显著减少。然而，尚不清楚这些峰值肌氧摄取(V̇mo2峰)的决定因素对COPD患者运动训练的反应。因此，本研究的目的是评估COPD患者骨骼肌V̇mo2峰O2转运决定因素的可塑性。测量了8例重度COPD患者(1秒用力呼气量(FEV1)±sem=0.9±0.1 l)和8例健康、匹配良好的对照者对8周单腿膝伸肌运动训练的适应性。利用股动脉和静脉血样本，以及经热稀释评估的腿血流量来测定最大运动前后肌肉氧的运输和利用。训练增加了COPD患者的V̇mo2峰(从271±29到342±35 mL·min−1增加了约26%)和对照组(从418±37到553±41 mL·min−1增加了约32%)，恢复了COPD患者的V̇mo2峰仅到训练前对照组V̇mo2峰的约80%。肌肉扩散性O2输送在COPD(从6.6±0.9到9.1±0.9 mL·min·mmHg−1增加了~ 38%)和对照组(从10.4±0.7到14.1±0.8 mL·min·mmHg−1增加了~ 36%)中也有类似的增加，患者达到训练前控制值的~ 90%。相比之下，肌肉对流氧气输送仅在对照组显著增加(从688±57到865±69 mL·min - 1增加了约26%)，使COPD患者(438±45 vs 491±51 mL·min - 1)达到训练前控制值的约70%。运动训练使COPD中的肌肉弥散性O2运输基本恢复，但V̇mo2峰仍受肌肉对流性O2运输可塑性的限制。脚注本手稿最近已被接受发表在欧洲呼吸杂志。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Broxterman reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Wagner reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Richardson reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;. ER -