Ty-jour t1 - 慢性阻塞性肺病的运动培训：肌肉o _{2 运输可塑性JF - 欧洲呼吸杂志Jo - Eur Respir J Do - 10.1183 / 13993003.04146-2020 SP - 2004146 Au - Broxterman，RyanM. Au - Wagner，Peter D. Au - Richardson，Russell S. Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/01/08/13993003.046-2020.AbstractN2 - 慢性阻塞性肺病（COPD）的患者中，对流O2传输和弥漫性运输在骨骼肌中，骨骼肌显着减少。然而，尚不清楚这些峰值肌肉O2摄取的决定因素（v̇mo2peak）如何响应COPD患者的运动培训。因此，本研究的目的是评估患有COPD的患者骨骼肌O2转运决定簇的可塑性。在8例严重COPD的8例患者中测量了单腿膝关节延伸的8周的8周（强制呼气量在1 s（FEV1）±SEM = 0.9±0.1L）和8个健康，匹配的控制中。股动脉和静脉血液样品和热渗透评估的腿血流来确定肌肉O2运输和利用在最大运动前和后塔。两者中的COPD中的V 1MO2Peak增加（271±29至342±35毫升·min-1）和对照（通过418±37至553±41毫升·min-1），恢复V̇mo2peak，仅达到训练预训练的~80％。肌肉扩散O2转运在两种COPD中同样增加（从6.6±0.9至9.1±0.9 mL·min·mmHG-1）和对照（从10.4±0.7至14.1±0.8 ml·min·mmhg-1），患者达到培训预训练控制值的约90％。相比之下，肌肉对流O2转运仅在对照中显着增加（从688±57至865±69 ml·min-1），将COPD患者（438±45与491±51毫升·min-1相比）在预训练中的~70％的培训中。当COPD中的肌肉扩散O2运输在很大程度上被运动训练恢复，V̇mo2peak在肌肉对流O2运输中受到限制的可塑性约束。最近被接受在欧洲呼吸期刊上的出版物的情况下的血迹。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Broxterman reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Wagner reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;.Conflict of interest: Dr. Richardson reports grants from National Heart, Lung, and Blood Insitute, grants from U.S. Department of Veterans Affairs, during the conduct of the study;. ER -}