@article Peralta2000157, author = Peralta, Gabriela P.和Abellan, Alicia和Montazeri, Parisa和Basterrechea, Mikel和Esplugues, Ana和Gonz - lez-Palacios, Sandra和Roda, C - lina和Santa-Marina, Loreto和Sunyer, Jordi和Vrijheid, Martine和Casas, Maribel和Garcia-Aymerich, Judith，儿童早期发育与7岁时的肺功能有关:一项基于人群的前瞻性研究}，volume = {56}， number = {6}， location-id = {2000157}， year = {2020}， doi = {10.1183/13993003.00157-2020}， publisher ={欧洲呼吸学会}，188bet官网地址以前的研究将出生后的早期生长与后期的肺功能联系起来，但它们的解释受到用于评估儿童生长的方法的限制。我们的目的是评估儿童早期发育(通过4年的体重指数(BMI)轨迹测量)与7年的肺功能之间的关系。我们纳入了来自西班牙Infancia y Medio Ambiente以人口为基础的出生队列的1257名儿童。根据4年前通过潜在阶级增长分析确定的BMI轨迹，儿童早期成长被分为5类。这些轨迹不同出生大小({\ textquotedblleft} {\ textquotedblright}, {\ textquotedblleft} {\ textquotedblright}, {\ textquotedblleft} {\ textquotedblright})和BMI增加速度(慢{\ textquotedblleft} {\ textquotedblright}, {\ textquotedblleft} {\ textquotedblright})加速。我们使用多变量混合回归将这些轨迹与7年的肺功能(1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC和用力呼气流量(FEV1 /FVC占FVC的25 % 75 %))联系起来。相比,出生的孩子平均大小和慢BMI(参考),较高的儿童出生大小和加速BMI获得较高FVC \ % pred(3.3 \ %、95 \ %可信区间1.0 \ % {\ textendash} 5.6 \ %)和FEV1 / FVC \ %的pred较低(-1.5 \ %、95 \ %可信区间-2.9 \ % {\ textendash} -0.1 \ %)在7年。在出生体重较低和体重指数增加加快的儿童中也观察到类似的关联。 Children with lower birth size and slower BMI gain had lower FVC \% pred at 7 years. No association was found for FEF25{\textendash}75\%.Independently of birth size, children with accelerated BMI gain in early childhood had higher lung function at 7 years but showed airflow limitation. Children with lower birth size and slower BMI gain in early childhood had lower lung function at 7 years.Independently of birth size, children with accelerated BMI gain in early childhood had higher lung function at 7 years but showed airflow limitation. Children with lower birth size and slower BMI gain in early childhood had lower lung function at 7 years. https://bit.ly/308ZDtn}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/6/2000157}, eprint = {//www.qdcxjkg.com/content/56/6/2000157.full.pdf}, journal = {European Respiratory Journal} }