TY -的T1 -改变肺毛细血管血液volume in childhood sickle cell disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00379-2020 VL - 56 IS - 6 SP - 2000379 AU - Bokov, Plamen AU - Boizeau, Priscilla AU - Pautrat, Jade AU - Missud, Florence AU - Ba, Aissatou AU - Haouari, Zinédine AU - Denjean, André AU - Delclaux, Christophe AU - Benkerrou, Malika Y1 - 2020/12/01 UR - //www.qdcxjkg.com/content/56/6/2000379.abstract N2 - It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudry et al. [3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.Children with sickle cell disease have a pulmonary capillary blood volume that is already dilated at rest and that may initiate a restrictive defect https://bit.ly/2MRaqkcP. Bokov and C. Delclaux thank Nicole Beydon for initiating the subject of the present study. ER -