TY - JOUR T1 -测定墨西哥城居民的表型年龄。摩根富林明加速老化对肺功能的影响和结构-欧洲呼吸杂志》乔和J欧元做- 10.1183/13993003.国会- 2020.5115六世- 56 - 64 SP - 5115 AU -温迪亚Roldan称,Ivette AU - Fernandez-Plata,罗萨里奥AU -帕尔多,安妮AU -塞尔曼,Moises Y1 - 2020/09/07 UR - //www.qdcxjkg.com/content/56/suppl_64/5115.abstract N2 -介绍:表型年龄(PhA)比实际年龄更好地代表了与年龄相关的生物学失调和衰老过程的复杂性，但很难估计。最近，提出了一个基于多系统的老化方程来确定PhA。目的:评价我院老年人群肺原醛水平，并探讨其对肺结构和功能的影响。方法:采用综合实际年龄和9个与年龄相关的生物标志物的方程，对墨西哥城60岁无呼吸问题的774名居民进行PhA检测。我们将年龄分为加速老化和健康老化两类，前者表现为与实际年龄相差4岁，后者表现为与实际年龄相差4岁。采用问卷调查的方式对危险因素进行分析。采用高分辨率ct评估肺结构，采用FVC、FEV1、DLCO和6MWT评估肺功能。结果:13%的队列显示PhA加速，这与5个独立的老化生物标志物相证实，42%为正常PhA, 46%为健康PhA。 Compared with healthy aging, accelerated aging was associated with male gender (OR 4.4,95%CI 2.4-7.9;p<0.01), diabetes mellitus (OR 9.7,95%CI 5.5-17.2;p<0.01), and long-term sleep duration (OR 2.9,95%IC 1.34-6.35,p<0.01). Subjects with accelerated aging showed a significant decrease in FVC(p<0.0001), FEV1(p<0.0001) and DLCO(p<0.02). In the HRCT, subjects with accelerated aging presented more frequently emphysematous lesions.Conclusions: 13% of the inhabitants of Mexico City age rapidly, which is associated with male gender, diabetes mellitus and long-term sleep duration.They exhibit lower levels of lung function and develop emphysema more frequently.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 5115.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -