PT -期刊文章AU - Drösslerová，玛丽AU - Šterclová，玛蒂娜AU - Vašáková，玛蒂娜AU - Tašková， Alice AU - Hytych, Vladislav AU - Richterová， Eva AU - Matějčková， Milada TI -趋化因子的作用，他们在可切除NSCLC中的基因多态性AID - 10.1183/13993003.国会-2020.4094 DP -2020年9月07 TA -欧洲呼吸杂志PG - 4094 VI - 56 IP -补充64 4099 - //www.qdcxjkg.com/content/56/suppl_64/4094.short 4100 - //www.qdcxjkg.com/content/56/suppl_64/4094.full SO - Eur Respir J2020年9月07;目的:趋化因子是针对肿瘤的免疫反应的一部分。趋化因子的表达受基因多态性的影响。它们在可切除NSCLC中的作用尚不清楚。目的:比较可切除NSCLC患者血浆中趋化因子浓度(CCL2、CCL8、CXCL12)与非NSCLC患者的差异。找出趋化因子浓度是否因疾病的不同阶段而不同。研究CCL2 rs3760396、CCL8 rs3138035、CXCL12 rs1804429基因多态性。研究非小细胞肺癌患者与非癌症患者的基因多态性是否存在差异。材料和方法:我们招募了69例接受NSCLC手术的患者(37名男性-平均年龄66岁，32名女性-平均年龄64岁)。 They underwent standard diagnostic and staging procedure. We diagnosed 42 patients with NSCLC, 27 patients had benign lung pathologies (control group). We assessed chemokine concentrations in peripheral blood by ELISA LSBio Kits. We assessed gene polymorphisms by quantitative real- time polymerase chain reaction with TaqMan hydrolysis probes. Parametric statistics was used for analysis.Results: There was no difference in concentrations of chemokines in plasma of NSCLC patients and control group. The CXCL12 concentrations positively corelated with the tumor extent expressed by clinical stage (mean values: stage I 5.08ng/ml; SEM 0.59; stage II and IIIA 7.82ng/ml; SEM 1.06; p= 0.022). There was no difference in gene polymorphisms between NSCLC patients and control group (CCL2 rs3760396 p= 0.160; CCL8 rs3138035 p= 0.589; CXCL12 rs1804429 p= 0.233).Conclusion: The CXCL12 relates tumor growth and might be a biomarker of advanced disease. We might need to include more patients to find out more about gene polymorphisms.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4094.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).