@article {Liang2000562作者={梁、文、关、Wei-jie和李Cai-chen和李,Yi-min梁,Heng-rui赵,彝族和刘,Xiao-qing和唱,凌和陈,Ru-chong和唐,春丽和王,道和王,小薇,他Qi-hua和陈,Zi-sheng和黄,Sook-San Zanin,马克和刘,小君和徐,鑫和黄,小君和李,Jian-fu Ou,李敏和程,Bo和熊,掸族和谢,Zhan-hong倪,Zheng-yi胡,Yu和刘,Lei山,洪教授和花环,Chun-liang彭,Yi-xiang和魏、李、刘、勇、胡Ya-hua彭,彭和Wang Jian-ming和刘,Ji-yang和陈,李钟和帮派和郑Zhi-jian和秋Shao-qin罗,杰,你们,长江、朱少勇、程林玲、叶诗玥、冯世平、郑金平、张诺甫、钟南山、何建兴}，标题={湖北(震中)和湖北以外(非震中)收治的新冠肺炎住院患者的临床特征和预后:A Nationwide Analysis of China}， location-id = {2000562}， year = {2020}， doi = {10.1183/13993003.00562-2020}， publisher ={欧洲188bet官网地址呼吸学会}，摘要={2019冠状病毒病(COVID-19)爆发期间的背景，已观察到，与中国其他地区相比，湖北省治疗的患者在疾病严重程度和死亡率方面存在一致和显著的差异。我们试图比较湖北省内外患者的临床特征和治疗结果，并探讨造成这些差异的因素。方法与国家卫健委合作，采用回顾性队列方法对我国住院的COVID-19病例进行研究。比较湖北境内外患者的临床特征、重症事件发生率、死亡率、危重症发生时间(有创通气或重症监护病房入院或死亡)。武汉市是湖北省的中心和行政中心，与武汉相关的暴露(可能是导致湖北重症疫情的关键因素)和发病到入院的时间对预后的影响也被确定。结果截止数据(2020年1月31日)，收集31个省级行政区575家医院的1590例病例(核心队列)。重症病例总感染率为16.0 %，病死率为3.2 %。湖北患者(以武汉相关暴露为主，597/647,92.3\%)年龄较大(平均: 49.7 versus 44.9 years), had more cases with comorbidity (32.9\% versus 19.7\%), higher symptomatic burden, abnormal radiologic manifestations, and, especially, a longer waiting time between symptom onset and admission (5.7 versus 4.5 days) compared with patients outside Hubei. Patients in Hubei [severe event rate 23.0\% versus 11.1\%, death rate 7.3\% versus 0.3\%, hazards ratio (HR) for critical illness 1.59, 95\%CI 1.05{\textendash}2.41] have a poorer prognosis compared with patients outside of Hubei after adjusting for age and comorbidity. However, among patients outside of Hubei, the duration from symptom onset to hospitalisation (mean: 4.4 versus 4.7 days) and prognosis (HR 0.84, 95\%CI 0.40{\textendash}1.80) were similar between patients with or without Wuhan-related exposure. In the overall population, the waiting time, but neither treated in Hubei nor Wuhan-related exposure, remained an independent prognostic factor (HR 1.05, 1.01{\textendash}1.08).Conclusion There were more severe cases and poorer outcomes for COVID-19 patients treated in Hubei, which might be attributed to the prolonged duration of symptom onset to hospitalisation in the epicenter. Future studies to determine the reason for delaying hospitalisation are warranted.This study highlights the necessity of urgent and vigorous support of healthcare resources and increased public awareness during the early stages of an outbreak of COVID-19 or similar diseases.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2020/04/01/13993003.00562-2020}, eprint = {//www.qdcxjkg.com/content/early/2020/04/01/13993003.00562-2020.full.pdf}, journal = {European Respiratory Journal} }