TY - T1的实验性呼吸困难影响智慧h locomotion and cognition: a randomised trial JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00054-2020 SP - 2000054 AU - Lawi, David AU - Dupuis, Elise-Lozeron AU - Berra, Gregory AU - Allali, Gilles AU - Similowski, Thomas AU - Adler, Dan Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/03/26/13993003.00054-2020.abstract N2 - Background Chronic respiratory diseases are associated with cognitive dysfunction, but whether dyspnea by itself negatively impacts on cognition has not been demonstrated. Cortical networks engaged in subjects experiencing dyspnea are also activated during other tasks that require cognitive input and may provoke a negative impact through interference with each other.Methods This crossover randomised trial investigated whether experimentally-induced dyspnea would negatively impact on locomotion and cognitive function among 40 healthy adults. Crossover conditions were unloaded breathing or loaded breathing using an inspiratory threshold load. To evaluate locomotion, participants were assessed by the Timed Up and Go test. Cognitive function was assessed by categorical and phonemic verbal fluency tests, the Trail Making Test A and B (executive function), the CODE test from the WAIS-IV (processing speed), and by direct and indirect digit span (working memory).Results The mean time difference to perform the Timed Up and Go test between unloaded and loaded breathing was −0.752 s (−1.012 to −0.492; p<0.001). Executive function, processing speed and working memory performed better during unloaded breathing, particularly for subjects starting first with the loaded breathing condition.Conclusion Our data suggest that respiratory threshold loading to elicit dyspnea had a major impact on locomotion and cognitive function in healthy adults.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lawi has nothing to disclose.Conflict of interest: Dr. Dupuis-Lozeron has nothing to disclose.Conflict of interest: Dr. Berra has nothing to disclose.Conflict of interest: Dr. Allali has nothing to disclose.Conflict of interest: Dr. SIMILOWSKI reports personal fees from AstraZeneca France, personal fees from Boerhinger Ingelheim France, personal fees from GSK France, personal fees and non-financial support from Novartis France, personal fees from TEVA France, personal fees from Chiesi France, personal fees from Lungpacer Inc, personal fees from ADEP Assistance, grants from Air Liquide Medical Systems, outside the submitted work.Conflict of interest: Dr. Adler reports grants from The Geneva Pulmonary League, during the conduct of the study. ER -