TY - T1的揭秘morphomolecular阿尔特拉tions of vasculature in interstitial lung diseases JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02446-2019 VL - 55 IS - 3 SP - 1902446 AU - Yanagihara, Toyoshi AU - Jones, Kirk D. Y1 - 2020/03/01 UR - //www.qdcxjkg.com/content/55/3/1902446.abstract N2 - Interstitial lung diseases (ILDs) encompass a complex group of hundreds of lung disorders that affect lung tissue with variable morphologies and clinical presentations. The most extensively studied type of ILD is idiopathic pulmonary fibrosis (IPF), which is characterised by progressive pulmonary fibrosis, a decline in lung function, and high mortality with a histological pattern of usual interstitial pneumonia (UIP). A proportion of patients with other types of ILD also develop a progressive fibrosing phenotype, including idiopathic nonspecific interstitial pneumonia (NSIP), as well as restrictive allograft syndrome (RAS) and idiopathic pleuroparenchymal fibroelastosis (iPPFE) with a histological pattern of alveolar fibroelastosis (AFE). RAS is a novel form of chronic lung allograft dysfunction first described in 2011 [1].Focusing on remodelling-associated angiogenesis, both sprouting and intussusceptive, Ackermann and co-workers present histopathology, microvascular anatomy and gene expression in three main subtypes of interstitial lung disease: UIP, NSIP and AFE http://bit.ly/2NtmV6D ER -