TY - JOUR T1 -妊娠期和儿童呼吸和特应性预后的地中海饮食:出生队列研究JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01215-2019 VL - 55 IS - 3 SP - 1901215 AU - BédardSeif O. Y1 - 2020/03/01 UR - //www.qdcxjkg.com/content/55/3/1901215.abstract N2 -怀孕期间地中海饮食与儿童哮喘、过敏和相关结果之间的关联的证据是相互矛盾的。很少有队列跟踪儿童到学龄，也没有人考虑肺功能。在《雅芳父母与儿童纵向研究》(Avon Longitudinal Study of Parents and Children)中，我们分析了怀孕期间母亲地中海饮食得分之间的关联(通过食物频率问卷估计，使用适合孕妇的先验定义得分;8907名7 - 9岁儿童的评分范围从0(低依从性)到7(高依从性)，以及目前医生诊断的哮喘、哮鸣、湿疹、花粉热、特应性和肺功能。研究了孕妇地中海饮食与孕妇孕期吸烟之间的相互作用。母亲地中海饮食评分与哮喘或其他过敏结果无关。在控制混杂因素后，发现母亲地中海饮食评分与儿童最大呼气流量(在强迫肺活量的25-75%时的强迫呼气流量(FEF25-75%))之间存在弱正相关。较高的地中海饮食得分与经年龄、身高和性别调整后的FEF25-75% z得分的增加相关(β 0.06, 95% CI 0.01-0.12;P =0.03，分别为4-7和0-3)。 Stratifying associations by maternal smoking during pregnancy showed that associations with FEF25–75% were only seen in children of never-/passive-smoking mothers, but no evidence for a statistically significant interaction was found.Results suggest adherence to a Mediterranean diet during pregnancy may be associated with increased small airway function in childhood, but we found no evidence for a reduced risk of asthma or other allergic outcomes.Adherence to a Mediterranean diet during pregnancy is not associated with a reduced risk of asthma or other allergic outcomes in the offspring, but may be associated with increased small airway function in childhood http://bit.ly/382yGcF ER -