%0刊期刊文章%Brazzale,Danny J.%A Seccombe,Leigh M.%A Welsh,Liam%A Lanteri,Celia J.%A Farah,Claude S.%A Ruehland,沃伦R.%T效应采用全球肺功能倡议2017年参考方程对一氧化碳转移因子%D 2020%R 10.1183 / 13993003.01905-2019%J1905-2019%J1905-2019%J1905%P 1901905%X最近发表的全球肺功能倡议(GLI)一氧化碳转移因子(TLCO)参考方程提供了采用当前,全年广泛应用参考集的机会。本研究的目的是记录从临床肺功能解释到TLCO结果的常用参考方程从通常使用的参考方程改变GLI的效果。来自临床肺功能分析了三家澳大利亚教学医院范围内的实验室。使用GLI和其他常用的参考方程计算该值下方的正常(LLN)和TLCO患者比例的患者的比例。GLI的平均TLCO LLN与其他方程相似或低,具有最大的差异CRAPO方程(中位数:-1.25,IQR:-1.64,0.86 mmol·min-1·KPA-1)。这些差异导致Gli的降低的TLCO率改变,特别是对于成人(+ 1.9%对-27.6%而与CRAPO),比儿童更多(-0.8%与Kim为-14.2%与Cotes)。对于成人来说,Gli的最高原始协议与米勒方程(94.7%),而对于儿童为KIM方程式(98.1%)。结果对年轻成年人和成年女性更频繁地重新分类到正常情况,特别是当从罗卡转移到Gli方程时(30%的女性与16%的男性)。成年人的GLI TLCO参考方程的采用将导致根据先前使用的等式以及成年女性更大程度的等式改变了解释。 The effect on interpretation in children is less significant.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Mr. Brazzale has nothing to disclose.Conflict of interest: Dr. Seccombe has nothing to disclose.Conflict of interest: Dr. Welsh has nothing to disclose.Conflict of interest: Dr. Lanteri has nothing to disclose.Conflict of interest: Dr. Farah has nothing to disclose.Conflict of interest: Dr. Ruehland has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2020/02/26/13993003.01905-2019.full.pdf