RT杂志文章SR Electronic T1纤维化间质性肺病的功能老化:摩根富林明的弱点在不良健康结果的影响欧洲呼吸杂志乔欧元和J FD欧洲呼吸学会SP 1900647 10.1183/13993003.00647 -2019签证官55是1 A1古尔,萨比娜a A1关颖珊188bet官网地址,乔安妮·m·A1梁,贾尼斯·m·A1哈利勒,Nasreen A1 Wilcox,皮尔斯g . A1瑞尔森生物学和功能性加速衰老在纤维化间质性肺病(ILD)中很常见;然而，它们对这一人群不良健康结果的影响尚未得到评估。方法前瞻性地从专门的ILD诊所招募患者。功能衰老是通过衰弱指数来确定的，生物学年龄是通过测量患者外周血白细胞的绝对端粒长度(aTL)来确定的。不良健康结果包括与健康相关的生活质量(圣乔治呼吸问卷)、呼吸性和非呼吸性住院次数和时间、药物耐受性和死亡或肺移植时间。使用多变量模型来确定与虚弱指数和aTL相关的不良健康结局的风险和比率。结果540例纤维化性ILD患者，其中特发性肺纤维化(IPF)患者100例，衰弱指数评估749例，其中189例提供血液样本。虚弱指数与生活质量、住院率、出院时间和死亡率密切相关，包括调整年龄、性别、疾病严重程度和IPF诊断。通过在常用的临床参数和之前验证过的综合指数中加入虚弱指数，死亡率预测得到了改善。 Conversely, aTL was not associated with most adverse health outcomes. The effect of chronological age on outcomes was mediated primarily by the frailty index, and to a lesser extent by aTL.Conclusions Functional ageing is associated with adverse health outcomes in patients with fibrotic ILD, indicating the need for consideration of the individual functional age into clinical decision-making.Frailty independently predicts adverse health outcomes in patients with fibrotic ILD; with functional ageing as the main driver of most age-related adverse health outcomes there is a need to recognise, prevent and treat frailty in this population http://bit.ly/2k81rRc