2018年9月29日讯/生物技术/生物医学进展(bioon / bioon / bioon)PA5421六世- 54 - 5 63 SP - PA5421盟Goyal贾格迪什普拉萨德盟-库马尔,Prawin AU -辛格,萨钦Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA5421.abstract N2 -背景:血嗜酸性粒细胞嗜酸性的标志气道炎症和血液中性粒细胞计数可能与疾病的严重程度和有关哮喘控制不佳。据观察，高血嗜酸性粒细胞计数的儿童吸入糖皮质激素(ICS)反应更好。目的和目的:本研究的目的是确定血液嗜酸性粒细胞和中性粒细胞计数与哮喘控制之间的关系。方法:这项回顾性队列研究使用了过去2年在印度三级保健中心儿科胸部门诊(PCC)就诊的儿童的病历数据。我们记录了基线人口统计资料、血液嗜酸性粒细胞和中性粒细胞计数。随访时按照GINA指南评估哮喘控制情况。同时记录ICS持续时间和PEFR。结果:在过去两年中，共有742名儿童参加了PCC治疗，其中116名哮喘儿童进行了血液嗜酸性粒细胞和中性粒细胞基线计数。本研究中位血嗜酸性粒细胞计数(IQR)为4%(1.3-6.9)，中位血中性粒细胞计数(53.5%)为42.2-66.4。 Eosinophil count was significantly high in children with well controlled asthma [median eosinophil count 4.4 % (IQR 1.7–8.1) vs 3.45 % (0.1-6.2)] [p=0.04]; while neutrophil counts were higher in children with partly/uncontrolled asthma as compared to well controlled asthma [median neutrophil count 59.4 % (IQR 59-69.4) vs 50.4% (38.9-65)] [p=0.02].Conclusion: Baseline high blood eosinophil counts were associated with better asthma control while baseline high neutrophil counts were associated with poor asthma control.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5421.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -