TY -的T1 ventri诊断精度cular trabecular mass measurements as measured on cardiac MRI in suspected pulmonary hypertension JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA5459 VL - 54 IS - suppl 63 SP - PA5459 AU - Macdonald, Alistair AU - Johns, Chris AU - Garg, Pankaj AU - Cogliano, Marcella AU - Condliffe, Robin AU - Wild, Jim AU - Kiely, David AU - Swift, Andrew Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA5459.abstract N2 - Introduction: Right ventricular (RV) trabecular mass is proportionally larger in patients with pulmonary hypertension (PH), however the value of including RV trabeculation during cardiac MRI (cMRI) analysis is not clear.Aim: Investigate the value of cMRI trabecular mass measurements in diagnosing patients with suspected pulmonary hypertension.Methods: A prospective cohort of 144 patients underwent MRI and right heart catheter (RHC) within 48 hours. RV diastolic epicardial and endocardial contours were manually drawn and a semi-automatic pixel intensity-based thresholding tool applied. Trabecular, compacted (between epi- and endocardial contours) and total mass were calculated. Pearson correlations were calculated between MRI and RHC metrics. Diagnostic accuracy of parameters was investigated using receiver operating characteristic curve. Diagnosis was defined as mean pulmonary arterial pressure≥25mmHg, then mPAP>20mmHg. RV mass measurements were indexed for left ventricular mass.Results: Trabecular mass correlated more strongly with mPAP (r=0.654) and pulmonary vascular resistance (r=0.632) than RV total mass (0.589,0.626) and compacted mass (0.248,0.377) with the same RHC metrics. With PH defined as mPAP≥25mmHg, area under the curve was significantly higher for both RV trabecular mass (AUC=0.813,p=0.002) and RV total mass (0.770,p=0.018), compared to compacted mass (0.606). With PH defined as mPAP>20, trabecular mass (0.818) was better than total mass (0.803) and compacted mass (0.703), but not significantly.Conclusion: Measurement of trabecular mass leads to increased diagnostic accuracy of cMRI in patients with suspected pulmonary hypertension.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5459.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -