PT -期刊文章盟Tello Khodr AU - Dalmer,安东尼娅AU - Vanderpool,丽贝卡盟——Ghofrani·侯赛因·a . AU - Naeije罗伯特AU -辊,Fritz AU -西格,Werner盟——Dumitrescu丹尼尔盟——萨默Natascha盟——Brunst安妮AU -胆,亨宁非盟-里希特曼努埃尔·j·TI -右心室lusitropy受损与通气效率低下的肺动脉高血压援助- 10.1183/13993003.00342 -2019 DP - 2019年11月01 TA -欧洲呼吸杂志》第六PG - 1900342 - 54 IP - 4099 - //www.qdcxjkg.com/content/54/5/1900342.short 4100 - 5//www.qdcxjkg.com/content/54/5/1900342.full SO - Eur Respir J2019 Nov 01;54 AB -心肺运动试验(CPET)是评估肺动脉高压(PAH)患者功能能力和预后的重要工具。然而，CPET参数与右心室(RV)功能适应后负荷的关系尚不完全清楚。在本研究中，37例PAH患者(其中31例特发性)进行了单搏压-容量环路测量右心室收缩期末弹性(Ees)、动脉弹性(Ea)和舒张期弹性(Eed)。通过磁共振成像评估肺动脉硬度。结果与CPET变量相关。使用logistic回归分析评估右心室功能参数与临床相关呼吸无效(定义为分钟通气/二氧化碳生产(V 'E /V 'CO2)斜率>48)的预测相关性。V 'E /V 'CO2斜率中位(四分位差)为42 (32-52)，V 'E /V 'CO2最低点为40(31-44)。呼气末二氧化碳压力峰值(PETCO2)的平均±sd为23±8 mmHg。 Ea, Eed and parameters reflecting pulmonary arterial stiffness (capacitance and distensibility) correlated with the V′E/V′CO2 slope, V′E/V′CO2 nadir, PETCO2 and peak oxygen pulse. RV Ees and RV–arterial coupling as assessed by the Ees/Ea ratio showed no correlations with CPET parameters. Ea (univariate OR 7.28, 95% CI 1.20–44.04) and Eed (univariate OR 2.21, 95% CI 0.93–5.26) were significantly associated with ventilatory inefficiency (p<0.10).Our data suggest that impaired RV lusitropy and increased afterload are associated with ventilatory inefficiency in PAH.Right ventricular diastolic stiffness and afterload (pressure–volume loop measurement) are associated with ventilatory inefficiency during exercise and may contribute to dyspnoea via increased chemosensitivity in pulmonary arterial hypertension http://bit.ly/30lLy9t