TY - JOUR T1 -绝经年龄和肺功能:孟德尔随机研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.02421 -2018欧元六世- 54 - 4 SP - 1802421 AU -范德Plaat,戴安娜a . AU -佩雷拉,米格尔AU - Pesce,吉安卡洛非盟,Potts詹姆斯·f . AU - Amaral安德烈F.S.盟——Dharmage Shyamali c . AU - Garcia-Aymerich Judith m . AU -汤普森约翰·r . AU -戈麦斯的旧金山AU -贾维斯,黛博拉·l . AU -史,Cosetta盟,研究新兴市场A2 - Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1802421.abstract N2 -在观察性研究中,早期的更年期是降低用力肺活量(FVC)和肺活量的限制的风险更高,但不是气流阻塞。然而，目前尚不清楚这种联系是否具有因果关系。因此，我们采用孟德尔随机化(MR)方法评估自然绝经年龄对肺功能的影响，该方法不受经典混杂效应的影响。我们纳入了来自英国生物银行的94742名自然绝经后妇女，并对绝经年龄对1秒用力呼气量(FEV1)、FVC、FEV1/FVC、肺活量限制(FVC<正常下限(LLN))和气流阻塞(FEV1/FVC<LLN)的影响进行了MR分析。我们使用逆方差加权方法，以及调整多效性的方法，并将MR与观察性分析进行比较。MR分析显示，与正常(45 - 55岁)绝经期妇女相比，早期(<45岁)绝经期妇女的FEV1/FVC较高，气流阻塞的风险降低15%。尽管有一些多效性的证据，但当使用MR方法对多效性稳健时，结果是一致的。 Similar results were found among never- and ever-smokers, while the protective effect seemed less strong in women who had ever used menopause hormone treatment and in overweight women. There was no strong evidence of an association with FVC or spirometric restriction. In observational analyses of the same dataset, early menopause was associated with a pronounced reduction in FVC and a 13% higher risk of spirometric restriction.Our MR results suggest that early menopause has a protective effect on airflow obstruction. Further studies are warranted to better understand the inconsistency with observational findings, and to investigate the underlying mechanisms and role of female sex hormones.Mendelian randomisation, an approach not affected by classical confounding, shows that early menopause has a protective effect on airflow obstruction. This points to the importance of investigating the effects of female sex hormones on the airways. http://bit.ly/2JAZuXh ER -