RT Journal第SR电子T1时代更年期和肺功能：孟德利安随机化研究JF欧洲呼吸期刊Jo EUR Respir J FD欧洲呼吸协会SP 1802421 Do 10.1183 / 13993003.02421-2018 VO 54是4 A1 Van der Plaat，Diana A. A1188bet官网地址Pereira, Miguel A1 Pesce, Giancarlo A1 Potts, James F. A1 Amaral, André F.S. A1 Dharmage, Shyamali C. A1 Garcia-Aymerich, Judith M. A1 Thompson, John R. A1 Gómez Real, Francisco A1 Jarvis, Deborah L. A1 Minelli, Cosetta A1 Leynaert, Bénédicte YR 2019 UL //www.qdcxjkg.com/content/54/4/1802421.abstract AB In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function.We included 94 742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1 s (FEV1), FVC, FEV1/FVC, spirometric restriction (FVC