作者@article {van der Plaat1802421 = {van derPlaat, Diana A. and Pereira, Miguel and Pesce, Giancarlo and Potts, James F. and Amaral, Andr{\'e} F.S. and Dharmage, Shyamali C. and Garcia-Aymerich, Judith M. and Thompson, John R. and G{\'o}mez Real, Francisco and Jarvis, Deborah L. and Minelli, Cosetta and Leynaert, B{\'e}n{\'e}dicte}, editor = {,}, title = {Age at menopause and lung function: a Mendelian randomisation study}, volume = {54}, number = {4}, elocation-id = {1802421}, year = {2019}, doi = {10.1183/13993003.02421-2018}, publisher = {European Respiratory Society}, abstract = {In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function.We included 94 742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1 s (FEV1), FVC, FEV1/FVC, spirometric restriction (FVC\