PT-期刊文章AU-珀森，Carl Ti- 体内观察结果提供了对哮喘辅助中嗜酸性粒细胞和上皮细胞角色的见解-10.1183/13993003.00470-2019-1900470 VI -54 IP -4 4099 -http：//www.qdcxjkg.com/content/54/4/4/1900470.short 4100 -http：//www.qdcxjkg.com/content/54/4/4/4/1900470.fullllll因此-UR EUR RESSIR J2019 10月1日；54 AB-在体内数据支持的患者体内观察体内，从这个角度来看，在中心阶段。它的目的是突出体内观察到的哮喘特征和涉及细胞/分子生物学研究范例的接受观点之间的二分法。例如，增加支气管上皮通透性现在被认为是哮喘的主要范围和特征，但是，在哮喘中，体内并未增加吸入的示踪剂的吸收。渗出性哮喘中这种维持的屏障功能反映了上皮衬里的体内不对称性，作为分子和细胞内部和内部世界之间的屏障。在排序性哮喘中，可以通过体内表现出极大的上皮损失，迅速产生等离子体衍生的临时屏障和高速上皮再生来解释维持的上皮紧绷。在这里，上皮细胞在体外的公认蛋白质/肽分泌与血浆衍生的蛋白质/肽（包括抗菌肽）体内的显性单向运动形成鲜明对比。此外，长期以来，声称上皮生产的腺苷是哮喘的介体受到哮喘患者体内观察的侵蚀。 Notions concerning activation/fate of mucosal tissue eosinophils illustrate additional distinctions between accepted views and in vivo patient observations. Finally, in vitro-based paradigms preaching defect epithelial regeneration and increased permeability in pathogenesis of asthma are contrasted with experimental in vivo observations of exaggerated epithelial regeneration, which is multipathogenic in its own right. In conclusion, unexpected and challenging in vivo observations in recent decades underpin novel insights into mucosal mechanisms in asthma.Exploratory in vivo research approaches produce unexpected discoveries and novel understanding independent of currently accepted paradigms http://bit.ly/2YgLdnF