TY - JOUR T1 -与结节病肺功能相关的胸部高分辨率计算机断层扫描放射学测量JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.00371 VL - 54 IS -2 SP - 1900371 AU - Ryan, Sarah M. AU - Fingerlin, Tasha E. AU - Mroz, Margaret AU - Barkes, Briana AU - Hamzeh, Nabeel AU - Maier, Lisa A. AU - Carlson，Nichole E. Y1 - 2019/08/01 UR - //www.qdcxjkg.com/content/54/2/1900371.abstract N2 -简介肺结节病是一种罕见的异质性肺部疾病，病因不明，治疗方案有限。表型依赖于临床测试，包括胸片的视觉评分。来自高分辨率计算机断层扫描(HRCT)的客观放射测量可提供评估疾病状况的额外信息。作为结节病的第一个放射组学分析，我们通过评估1)结节病受试者与健康对照之间HRCT的差异，2)放射组学测量与肺活量测量之间的相关性，3)Scadding阶段之间的趋势，研究了放射组学测量作为结节病生物标志物的潜力。方法在HRCT上计算3个解剖平面的放射学特征。线性回归比较了结节病受试者(n=73)和健康对照组(n=78)的整体放射特征，并确定了与肺活量测定的相关性。使用功能数据分析研究了肺内关联的空间差异。亚分析比较了各洗涤阶段的辐射特征。结果结节病受试者和对照组的整体放射组测量值差异显著(p<偏度、峰度、分形维数和Geary's C为0.001)，空间放射组学差异在上部和外侧区域最为明显。在结节病受试者中，放射学测量与肺活量测量之间存在显著相关性，Geary's C与用力肺活量(FVC)之间存在很大相关性(p=0.008)。 Global radiomic measures differed significantly between Scadding stages (p<0.032), albeit nonlinearly, with stage IV having more extreme radiomic values. Radiomics explained 71.1% of the variability in FVC compared with 51.4% by Scadding staging alone.Conclusions Radiomic HRCT measures objectively differentiate disease abnormalities, associate with lung function and identify trends in Scadding stage, showing promise as quantitative biomarkers for pulmonary sarcoidosis.Radiomic measures identify pulmonary parenchymal abnormalities in sarcoidosis and are highly associated with lung function, suggesting that radiomics could enhance visual reads and result in improved patient profiling, disease staging and monitoring. http://bit.ly/2HMLaKm ER -