RT期刊文章SR电子T1 Radiomic措施从胸部高分辨率计算机断层扫描与肺功能在结节病摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1900371 10.1183/13993003.00371 -2019签证官54 2 A1瑞安,莎拉·m·A1 Fingerlin塔莎大肠A1 Mroz,玛格丽特A1树皮,对此A1 Hamzeh, Nabeel A1麦尔,丽莎a A1卡尔森,尼科188bet官网地址尔·e·年2019 UL //www.qdcxjkg.com/content/54/2/1900371.abstract AB介绍肺结节病是一种罕见的异构肺病的原因不明,有限的治疗方案。表现型依靠临床试验包括胸片的视觉评分。客观radiomic措施从高分辨率计算机断层扫描(HRCT)可能提供额外的信息来评估疾病状态。作为第一个radiomics分析结节病,我们调查的潜力radiomic措施作为结节病的生物标记物,通过评估1)HRCT结节病主题和健康对照组之间的差异,2)之间的关联radiomic措施和肺量测定法,和3)趋势之间的许多阶段。方法Radiomic特性计算在HRCT在三个解剖的飞机。结节病学科之间的线性回归相比全球radiomic特性(n = 73)和健康对照组(n = 78)、和识别对肺量测定法。空间差异在肺协会进行了使用功能数据分析。相比subanalysis radiomic特性之间的许多阶段。结果全球radiomic措施结节病学科和控制之间的差距显著(p < 0.001为偏态、峰态分形维数和Geary C),空间的差异radiomics优越和横向地区最为明显。结节病学科,有重大关系radiomic措施和肺量测定法,与一个大型协会发现Geary C和之间的用力肺活量(FVC) (p = 0.008)。竹荚鱼阶段之间全球radiomic措施明显不同(p < 0.032),尽管非线性,第四阶段有更极端的radiomic值。 Radiomics explained 71.1% of the variability in FVC compared with 51.4% by Scadding staging alone.Conclusions Radiomic HRCT measures objectively differentiate disease abnormalities, associate with lung function and identify trends in Scadding stage, showing promise as quantitative biomarkers for pulmonary sarcoidosis.Radiomic measures identify pulmonary parenchymal abnormalities in sarcoidosis and are highly associated with lung function, suggesting that radiomics could enhance visual reads and result in improved patient profiling, disease staging and monitoring. http://bit.ly/2HMLaKm