TY -的T1 Radiomic措施从胸部高分辨率计算机断层扫描与结节病肺功能有关摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00371 -2019欧元六世- 54 - 2 SP - 1900371 AU -瑞恩,莎拉·m . AU - Fingerlin,塔莎e . AU - Mroz玛格丽特盟——树皮,对此非盟- Hamzeh Nabeel AU -迈尔,丽莎·a . AU -卡尔森,尼科尔·e·Y1 - 2019/08/01 UR - //www.qdcxjkg.com/content/54/2/1900371.abstract N2 -介绍肺结节病是一种罕见的异构肺病的原因不明,有限的治疗方案。表现型依靠临床试验包括胸片的视觉评分。客观radiomic措施从高分辨率计算机断层扫描(HRCT)可能提供额外的信息来评估疾病状态。作为第一个radiomics分析结节病,我们调查的潜力radiomic措施作为结节病的生物标记物,通过评估1)HRCT结节病主题和健康对照组之间的差异,2)之间的关联radiomic措施和肺量测定法,和3)趋势之间的许多阶段。方法Radiomic特性计算在HRCT在三个解剖的飞机。结节病学科之间的线性回归相比全球radiomic特性(n = 73)和健康对照组(n = 78)、和识别对肺量测定法。空间差异在肺协会进行了使用功能数据分析。相比subanalysis radiomic特性之间的许多阶段。Results Global radiomic measures differed significantly between sarcoidosis subjects and controls (p<0.001 for skewness, kurtosis, fractal dimension and Geary's C), with differences in spatial radiomics most apparent in superior and lateral regions. In sarcoidosis subjects, there were significant associations between radiomic measures and spirometry, with a large association found between Geary's C and forced vital capacity (FVC) (p=0.008). Global radiomic measures differed significantly between Scadding stages (p<0.032), albeit nonlinearly, with stage IV having more extreme radiomic values. Radiomics explained 71.1% of the variability in FVC compared with 51.4% by Scadding staging alone.Conclusions Radiomic HRCT measures objectively differentiate disease abnormalities, associate with lung function and identify trends in Scadding stage, showing promise as quantitative biomarkers for pulmonary sarcoidosis.Radiomic measures identify pulmonary parenchymal abnormalities in sarcoidosis and are highly associated with lung function, suggesting that radiomics could enhance visual reads and result in improved patient profiling, disease staging and monitoring. http://bit.ly/2HMLaKm ER -