％0期刊论文％A RAHAGHI，Farbod N.％的Argemí，杰玛％A纳德利，彼得％A多明戈斯 - Fandos，大卫％A阿尔吉斯，佩德罗％A Peinado，维克托一％A·罗斯，詹姆斯C.％A灰塞缪尔Y.％A德拉要么就让，艾萨克％A来，卡罗琳E.％A·迪亚兹，亚历杭德罗·A.％A桑切斯，马塞洛％A Washko，乔治·R％A巴贝拉，琼阿尔伯特％圣何塞埃斯特帕尔，劳尔％T肺血管密度：结论在计算机断层摄影成像用组织学％d 2019％R 10.1183 / 13993003.00370-2019％Ĵ欧洲呼吸杂志％P 1900370％V 54％N 2％X背景暴露于香烟烟雾已经显示出比较导致血管重塑。血管修剪的计算机断层扫描（CT）成像的措施已与肺血管疾病，与吸烟相关的重要发病率有关。在这项研究中，我们比较远端血管损失的基于CT的措施，组织血管和实质changes.Methods A的80例谁经历了肺切除确定患者成像适用于三维（3D）血管重建（N = 18回顾性分析）和二维（2D）分析第二组（n = 19）。Measurements of the volume of the small vessels (3D) and the cross-sectional area of the small vessels (<5 mm2 cross-section) were computed. Histological measures of cross-sectional area of the vasculature and loss of alveoli septa were obtained for all subjects.Results The 2D cross-sectional area of the vasculature on CT imaging was associated with the histological vascular cross-sectional area (r=0.69; p=0.001). The arterial small vessel volume assessed by CT correlated with the histological vascular cross-sectional area (r=0.50; p=0.04), a relationship that persisted even when adjusted for CT-derived measures of emphysema in a regression model.Conclusions Loss of small vessel volume in CT imaging of smokers is associated with histological loss of vascular cross-sectional area. Imaging-based quantification of pulmonary vasculature provides a noninvasive method to study the multiscale effects of smoking on the pulmonary circulation.Vascular density on CT imaging correlates with vascular density in histology in smokers. Imaging-based quantification of pulmonary vasculature provides a noninvasive method to study the multiscale effects of smoking on the pulmonary circulation. http://bit.ly/2WprQe8 %U //www.qdcxjkg.com/content/erj/54/2/1900370.full.pdf